I just finished replaying Phantasmagoria on my new computer and it actually worked perfectly for me without any tweaking whatsoever – didn’t even have to use XP’s compatibility mode or anything at all!
I’ll probably purchase these compilations if only because all the versions of the games I currently have are so worn out and scratched up that they barely work anymore anyway. It would be nice if they made them playable without emulation… but if not, I have VDMSound which works great with pretty much every single old game I have, and with far far less annoyance than using DOSBox.